OU749 Property

storage temp. 

2-8°C

solubility 

DMSO: >20mg/mL

form 

solid

color 

white to off-white

Safety

Hazard Codes 

Xn

Risk Statements 

22

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

OU749 Chemical Properties,Usage,Production

Biological Activity

ou749 is a competitive inhibitor of γ-glutamyl transpeptidase (ggt) [1].expression of γ-glutamyl transpeptidase (ggt) in tumors contributes to the resistance to radiation and chemotherapy. ggt is inhibited by glutamine analogues which compete with the substrate for the γ-glutamyl binding site [1].ou749 inhibited human kidney ggt with an intrinsic ki of 17.6 m [1]. in 786-o cells, a human renal tumor cell line, ou749 showed more than 150-fold less toxic than the ggt inhibitor acivicin toward dividing cells. ou749 inhibited ggt isolated from human kidney in a dose-dependent manner [1]. ou749 was 7-fold less potent as inhibitor of ggt isolated from rat kidney and 10-fold less potent inhibiting ggt from mouse kidney [1]. ou749 did not inhibit degradation of glutathione by ggt from rat kidney. inhibition of ggt by ou749 is species-specific [1]. ou749 showed no inhibitory effect on ggt from pig cells. ou749 inhibited human ggt expressed in mouse fibroblasts by a similar extent to the ggt from human cells, indicated that the species specificity was determined by differences in the primary structure of the protein rather than species-specific, post-translational modifications [1].

References

[1] king j b, west m b, cook p f, et al. a novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase[j]. journal of biological chemistry, 2009, 284(14): 9059-9065.